A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential
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چکیده
منابع مشابه
A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential.
The plant Geum japonicum Thunberg (GjT) has been used as a diuretic in traditional medicine. Herein, we report that the GjT extract blocks both the spread of human umbilical vein endothelial cells (HUVECs) on matrigel and the migration of B16 cells. We used various assays to test for cell attachment, spreading, wound healing and angiogenesis. A reverse transcription-polymerase chain reaction (R...
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Geumonoid (1), a new triterpene, was isolated from Geum japonicum. Its structure was elucidated on the basis of 1D, 2D NMR and MS spectroscopic analysis. Compound 1 showed inhibitory activity against HIV-1 protease.
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Bioassay-guided fractionation of the MeOH extract of Geum japonicum Thunb. var. chinense using the fatty acid synthase inhibition assay led to the isolation of a new dimeric ellagitannin, gemin G (1), together with six known compounds, gemin A (2), casuarinin (3), pedunculagin (4), potentillin (5) , tellimagrandin II (6), and ellagic acid (7). Their structures were determined on the basis of sp...
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Chronic coronary heart disease (cCHD) is characterized by atherosclerosis, which progressively narrows the coronary artery lumen and impairs myocardial blood flow. Restoration of occluded coronary vessels with newly formed collaterals remains an ideal therapeutic approach due to the need for redirecting blood flow into the ischemic heart. In this study, we investigated the effect of an active f...
متن کاملDepressor action and vasorelaxation of methylene chloride fraction extracted from Rubus coreanum
INTRODUCTION The present study was designed to examine whether methylene chloride (CH2Cl2) fraction extracted from Rubus coreanum affects the contractility of the isolated thoracic aortic strips and blood pressure of normotensive rats. METHODS One of the common carotid arteries or of the femoral arteries was catheterized with a polyethylene tubing. The tubing was connected to a pressure trans...
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ژورنال
عنوان ژورنال: Oncology Reports
سال: 2008
ISSN: 1021-335X,1791-2431
DOI: 10.3892/or.19.6.1399